Five of the Top 10 spots go to Quebec cities, with Sherbrooke topping the charts in Canadian Business magazine's sixth annual ranking. TORONTO, Sept. 11 /CNW/ - Alberta may be trendy, but if you're serious about business, Quebec's the place to be, according to this year's Canadian Business Best Cities for Business ranking. This year's Top 10 features five cities from la belle province. Sherbrooke, Que., tops Canadian Business's sixth annual ranking of the best places to set up a business. The city is the second-most export-intensive area in Quebec, and does a lot of business with the northeastern United States. For example, Charles Rivers Laboratories of Wilmington, Mass., recently announced it's moving to Sherbrooke, bringing an initial 200 jobs in high-skilled clinical testing. And the city has managed to keep unemployment at 5.7%, far below the Quebec average. While Sherbrooke's traditional industrial base floundered over the past several decades, the city has steadily created a knowledge-based economy to replace it. With eight post-secondary institutions, Sherbrooke has the highest concentrations of brains, students, and research and development on the continent, and contributes a billion dollars to the local economy. "The money came to Sherbrooke because the expertise was in Sherbrooke," says Quebec Premier Jean Charest.The Best Canadian Cities for Business: Rank City 1. Sherbrooke, Que. 2. Charlottetown, P.E.I. 3. Saguenay, Que. 4. Moncton, N.B. 5. Laval, Que. 6. Trois-Rivières, Que. 7. St. John's, Nfld. 8. Saint John, N.B. 9. Oshawa, Ont. 10. Longueuil, Que.The complete list and rank of each city in the Canadian Business Best Cities for Business ranking is available on newsstands today and through the contact below. Methodology The cities selected for the survey include the country's 25 largest cities, plus 15 smaller cities (for regional representation). Cities are ranked on five factors reflecting socio-economic health: the variable operating costs of doing business, the cost of living, non-residential permits and unemployment and crime rates. The final ranking weights each factor based on a Canadian Business online survey of 5,343 readers, rating the importance of the five criteria. Further details on methodology are available through the contact below. About Canadian Business magazine: Founded in 1928, Canadian Business is the longest-serving, bestselling and most trusted business publication in Canada. Canadian Business stands alone as the business magazine in Canada with 100% paid circulation. With a readership of almost one million, the magazine is published every second Monday, except in January, July and August, when monthly issues are published. Special annual issues of Canadian Business include the Investor 500, the MBA Guide, the Rich 100 and the Best and Worst Boards. Visit www.canadianbusiness.com/magazine.